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. 2015 Jun 24;10(6):e0127244. doi: 10.1371/journal.pone.0127244

Fig 6. Interaction between NRF2 gene variant and KEAP1 gene variants on intellectual ability in patients with schizophrenia.

Fig 6

(A): There was a significant (P = 0.0036) epistatic effect of NRF2 gene (rs10930781) and KEAP1 gene variant (rs1048290) on working memory in patients with schizophrenia, but not controls (S1 Table). On the other hand, a significant (P = 0.0035) effect of these variants on processing speed was due to the NRF2 gene variant. (B): There was a significant (P = 0.012) epistatic effect of NRF2 gene (rs10930781) and KEAP1 gene variant (rs11545829) on working memory in schizophrenia, but not controls (S2 Table). On the other hand, a significant effect (P = 0.0024) of these variants on processing speed in schizophrenia was due to the NRF2 gene variant (S2 Table).