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. 2015 May 21;4(7):764–774. doi: 10.5966/sctm.2014-0287

Figure 4.

Figure 4.

EM ASCs have higher uncoupled respiration compared with s.c. ASCs. (A): Plot of the relative OCRs of ASC cultures from s.c. and EM sources. Raw OCR values are first normalized by cellular density and then to s.c. average basal respiration. Drug injection sequence is noted by roman numerals: oligomycin (i), carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (ii), and rotenone and antimycin A (iii). (B): Plot of basal respiration in EM cultures compared with s.c. cultures. (C): Plot of uncoupled respiration. (D): Regression of uncoupling-linked genes UCP1 (a), CIDEA (b), and PGC1A (c) against uncoupled respiration. ∗, p < .05; ∗∗, p < .01. Abbreviations: ASCs, adipose-derived stem cells; EM, epimuscular; OCR, oxygen consumption rate.