Table 2. Baseline Characteristics of the Patients, in the Two Groups Analyzed.
| Variables | Treatment (group) | P-value* | |
|---|---|---|---|
| Biological (n=96) | Conventional (n=72) | ||
| Age (yr) | 32.1±11.4 | 34.3±12.6 | 0.220 |
| Duration of CD (mo) | 83 (2-300) | 30 (0-372) | <0.001* |
| Surgical specimen (cm) | 34.7±21.4 | 29.6±13.3 | 0.059 |
| Female gender | 37 (38.5) | 32 (44.4) | 0.526 |
| Montreal classification | |||
| Age at diagnosis | 0.064 | ||
| <16 yr (A1) | 10 (10.4) | 5 (6.9) | |
| 17-40 yr (A2) | 71 (74) | 45 (62.5) | |
| >40 yr (A3) | 15 (15.6) | 22 (30.6) | |
| Location | 0.015* | ||
| Ileal (L1) | 34 (35.4) | 38 (52.8) | |
| Colonic (L2) | 6 (6.3) | 0 (0) | |
| Ileocolonic (L3) | 56 (58.3) | 34 (47.2) | |
| Behavior | 0.340 | ||
| Inflammatory (B1) | 5 (5.2) | 2 (2.8) | |
| Stricturing (B2) | 51 (53.1) | 46 (63.9) | |
| Penetrating (B3) | 40 (41.7) | 24 (33.3) | |
| Smoking | 13 (13.5) | 12 (16.7) | 0.663 |
| Mean time of postoperative colonoscopy (mo) | 6.7±2.6 | 6.6±2.7 | 0.807 |
| Perianal disease | 31 (32.3) | 14 (19.4) | 0.079 |
| Concomitant steroids | 28 (29.2) | 23 (31.9) | 0.736 |
| Concomitant AZA/6-MP | 37 (38.5) | 16 (22.2) | 0.029* |
| Preoperative biologicals | 50 (52.1) | 3 (4.2) | <0.001* |
| Previous intestinal resections | 37 (38.5) | 13 (18.1) | 0.006* |
| Blood transfusion | 9 (10.6) | 7 (17.5) | 0.389 |
| Residual CD after surgery | 16 (16.7) | 11 (15.3) | 0.836 |
| Conventional procedure | 72 (75) | 34 (47.2) | <0.001* |
| Hand-sewn anastomosis | 23 (24) | 20 (27.8) | 0.596 |
| Side-to-side anastomosis | 73 (76) | 56 (77.8) | 0.855 |
| Early surgical complications | 15 (15.6) | 13 (18.1) | 0.682 |
| Abdominal Sepsis | 9 (9.4) | 6 (8.3) | 1.000 |
| Anastomotic dehiscence | 8 (8.3) | 4 (5.6) | 0.559 |
| Granuloma | 52 (54.2) | 24 (33.3) | 0.008* |
Values are presented as a n (%) or mean±SD.
*Indicates a statistical difference between the groups in relation to the variable analyzed.
AZA, azathioprine; 6-MP, 6-mercaptopurine.