Figure 8. Proposed model for the role of TRPC3 in hypertrophic scar contracture.

TRPC3 gene transcription is upregulated by mechanical stretching forces. Increased TRPC3 expression leads to increased calcium influx, which induces NFκB phosphorylation. Activated NFκB translocates into the nucleus and promotes Fibronectin gene expression, which ultimately enhances wound contraction.