Table 1. Fluorescein Angiography Findings in Behçet Retinal Vasculitis.
| Total | Peripheral vasculitis* | Vasculitis involving posterior pole† | p value¶ | ||||
|---|---|---|---|---|---|---|---|
| Total | Macular‡ | Extramacular§ | p value∥ | ||||
| Number of eyes (%) | 86 | 23 (26.7) | 63 (73.3) | 51 (59.3) | 12 (19.0) | NA | NA |
| Age (yrs) | 35.63±10.18 | 32.0±10.20 | 36.78±9.98 | 35.42±12.49 | 37.10±9.41 | 0.60†† | 0.067†† |
| HLA B-51 (%) | 35 (40.7) | 11 (47.8) | 24 (38.1) | 22 (34.9) | 2 (3.17) | 0.11** | 0.20** |
| Initial VA (logMAR) | 0.427±0.537 | 0.078±0.148 | 0.554±0.572 | 0.560±0.566 | 0.529±0.619 | 0.87†† | <0.0001†† |
| Follow-up VA§§ (logMAR) | 0.439±0.529 | 0.087±0.181 | 0.568±0.557 | 0.618±0.576 | 0.354±0.426 | 0.14†† | <0.0001†† |
| Follow-up duration (months) | 33.3±17.9 | 30.1±18.9 | 34.4±17.7 | 35.4±18.9 | 25.1±17.7 | 0.091†† | 0.33†† |
| Extent of leakage (%) | <0.0001** | ||||||
| Focal | 17 (19.8) | 17 (73.9) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0.99** | |
| Diffuse | 69 (80.2) | 6 (26.1) | 63 (91.3) | 51 (80.9) | 12 (19.1) | ||
| Degree of retinal vascular leakage (%) | 0.012‡‡ | <0.0001‡‡ | |||||
| Mild | 46 (53.5) | 22 (95.6) | 23 (36.5) | 14 (27.5) | 9 (75.0) | ||
| Moderate | 28 (32.6) | 1 (4.4) | 28 (44.4) | 26 (51.0) | 2 (16.7) | ||
| Severe | 12 (14.0) | 0 (0.0) | 12 (19.0) | 11 (21.6) | 1 (8.3) | ||
| Optic disc hyperfluorescence (%) | |||||||
| None | 15 (17.4) | 7 (30.4) | 8 (12.7) | 6 (11.8) | 2 (16.7) | 0.50‡‡ | 0.11‡‡ |
| Partial | 34 (39.5) | 8 (34.8) | 26 (41.3) | 23 (45.1) | 3 (25.0) | ||
| Diffuse with clear disc margin | 29 (33.7) | 8 (34.8) | 21 (33.3) | 15 (29.4) | 6 (50.0) | ||
| Diffuse with blurring of disc margin | 8 (9.3) | 0 (0.0) | 8 (12.7) | 7 (13.7) | 1 (8.3) | ||
| Ischemic change (%) | |||||||
| Peripheral Capillary nonperfusion | 15 (17.4) | 3 (13.0) | 12 (19.0) | 8 (15.7) | 4 (33.3) | 0.22‡‡ | 0.75‡‡ |
| Vascular anastomosis | 22 (25.6) | 0 (0.0) | 22 (34.9) | 17 (33.3) | 5 (41.7) | 0.74** | 0.002** |
| NVE | 2 (2.3) | 0 (0.0) | 2 (3.2) | 0 (0.0) | 2 (16.7) | 0.034** | 0.99** |
| NVD | 1 (1.2) | 0 (0.0) | 1 (1.6) | 1 (2.0) | 0 (0.0) | 0.99** | 0.99** |
| BRVO | 1 (1.2) | 0 (0.0) | 1 (1.6) | 1 (2.0) | 0 (0.0) | 0.99** | 0.99** |
| Macular ischemia | 7 (8.1) | 0 (0.0) | 7 (11.1) | 6 (11.7) | 1 (8.3) | 0.99** | 0.18** |
logMAR, logarithm of the minimum angle of resolution; VA, visual acuity; NVE, neovascularization elsewhere; NVD, neovascularization at disc; BRVO, branch retinal vein occlusion.
*Peripheral vasculitis refers to eyes with vascular leakage confined to the periphery (i.e., no involvement of the posterior pole).
†Vasculitis involving the posterior pole refers to eyes with vascular leakage that involves the posterior pole. All of these eyes also had vascular leakage in the periphery.
‡Macular subtype had involvement of the posterior pole region that included the central 1.5 mm area of the macula.
§Extramacular subtype showed involvement of the posterior pole but no evidence of macular leakage.
∥Comparison between the macular and extramacular subtypes.
¶Comparison between peripheral vasculitis and posterior pole-involved vasculitis.
**Pearson chi-square test (Fisher's exact test).
††Independent Student's t-test or Mann-Whitney U test.
‡‡Mantel-Haenszel chi-square test for trend analysis.
§§Follow-up VA at 2 year time point within a 3 month window; p-value<0.05 is considered statistically significant (indicated in italic).