Fig. 1. Serum concentrations of (A) moxifloxacin, (B) prothionamide, and (C) cycloserine in 29 MDR-TB patients. Hollow circles in (B and C) represent the assorted values marked in the conversion groups. The frequency of low serum concentrations of MF, PTH, and CS below the minimal normal range are described in the bottom line under each group. There were no differences between the 2-month sputum conversion group (n=25) and the 2-month sputum non-conversion group (n=4) in median drug concentration of MF, PTH, and CS. The median serum concentration in the 2-month sputum conversion group (n=25) and 2-month sputum non-conversion group (n=4) were as follows: (A) 1.46 µg/mL, IQR 0.33-2.17 vs. 1.60 µg/mL, IQR 0.93-2.54; (B) 0.93 µg/mL, IQR 0.35-2.34 vs. 0.70 µg/mL, IQR 0.24-1.28; and (C) 15.10 µg/mL, IQR 8.23-21.65 vs. 14.90 µg/mL, IQR 9.89-19.45. IQR, interquartile range; MDR-TB, multi-drug resistant tuberculosis; MF, moxifloxacin; PTH, prothionamide; CS, cycloserine.