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. 2015 Jun 25;5:11594. doi: 10.1038/srep11594

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(a,b) The detection of CD31-positive cells. Adenosine promoted late EPC differentiation in vitro. The autophagy inhibitor reversed adenosine-induced EPC differentiation, while the mTOR inhibitor markedly enhanced the differentiation of EPCs into endothelial cells. *p < 0.05 (n = 6) versus HG. ^#p < 0.05 (n = 6) versus adenosine. Values are the mean ± SE. (c,d) The ratio of differentiated EPCs in diabetic ischemic wounds. Late EPCs were stained with CM-Dil (red) and transplanted onto foot wounds in diabetic mice for 96 hours. The cells were stained with CD31 antibody (green). *p < 0.05 (n = 6) versus control. Values are the mean ± SE.