Table 2.

Simulation results for estimation of AUC of a single biomarker, comparing the proposed method with the WMR method cited from Table 3 of Saha-chaudhuri and Heagerty (2013). SD and SE are the empirical and model-based standard error estimates. CP is the calculated coverage probability of 95% confidence intervals.

		WMR			Proposed method
Log time	AUC(t)	Bias	SD	CP(%)	Bias	SD	SE	CP(%)
–2.5	0.378	–0.002	0.109	87.7	0.000	0.104	0.111	91.9
–2.0	0.481	–0.004	0.083	91.1	0.006	0.077	0.085	95.2
–1.5	0.591	0.004	0.062	92.0	0.000	0.059	0.065	96.0
–1.0	0.673	0.001	0.048	91.6	–0.006	0.043	0.047	96.0
–0.5	0.709	–0.001	0.035	93.7	–0.001	0.040	0.041	95.6
0.0	0.709	0.001	0.030	94.8	0.005	0.037	0.039	95.0
0.5	0.691	0.001	0.034	92.5	–0.003	0.054	0.051	93.0
1.0	0.669	0.000	0.042	93.9	–0.002	0.088	0.102	96.2