Table 3.

Simulation results for estimated difference between AUCs of two biomarkers, comparing the proposed method with the WMR method as cited from Table 2 of Saha-chaudhuri and Heagerty (2013). dAUC(t) is the true value of difference in AUCs at time point t. SD and SE are the empirical and model-based standard error estimates. CP is the calculated coverage probability of 95% confidence intervals.

		WMR			Proposed method
Log time	dAUC(t)	Bias	SD	CP(%)	Bias	SD	SE	CP(%)
			20% censoring
–2.0	0.101	–0.002	0.062	88.8	0.001	0.060	0.063	88.7
–1.5	0.098	–0.002	0.040	94.5	0.000	0.036	0.041	96.6
–1.0	0.091	–0.001	0.032	94.6	–0.001	0.028	0.033	96.4
–0.5	0.080	–0.002	0.029	94.8	0.000	0.025	0.029	96.2
0.0	0.070	–0.001	0.030	94.9	–0.001	0.027	0.030	96.0
0.5	0.060	0.000	0.037	93.2	0.000	0.037	0.037	96.9
1.0	0.051	0.002	0.054	93.3	0.001	0.069	0.061	91.1
			40% censoring
–2.0	0.101	–0.002	0.062	88.8	0.000	0.068	0.063	89.0
–1.5	0.098	–0.002	0.041	94.7	0.000	0.039	0.042	95.3
–1.0	0.091	–0.001	0.033	95.0	–0.001	0.031	0.034	96.0
–0.5	0.080	–0.001	0.031	94.8	–0.001	0.030	0.032	96.4
0.0	0.070	0.001	0.035	94.5	–0.002	0.032	0.036	96.9
0.5	0.060	0.001	0.048	94.8	0.003	0.055	0.053	94.4
1.0	0.051	0.002	0.100	93.3	–0.008	0.258	0.266	85.8