Table 3.

Patient and Disease Characteristics Associated with the Presence of Numbness/Tingling at the Initial Assessment

		Model 1 Outcome: ≥5 Numbness/ Tingling (n=2910^a)			Model 2 Outcome: Numbness/Tingling Rated as One of Top 3 Symptoms by Clinician (n=2925^b)

Variables	Levels	OR	95% CI	P-value	OR	95% CI	P-value
Disease site	Colorectal vs. others	1.66	1.34–2.05	<0.001	2.95	2.07–4.19	<0.001
Age (yrs)	Continuous	0.99	0.98–1.00	0.007	1.00	0.99–1.01	0.998
Years since diagnosis	Continuous	1.02	1.00–1.04	0.036	1.01	0.98–1.03	0.671
Race	Black v. White	2.02	1.55–2.63	<0.001	1.22	0.75–1.98	0.426
	Other v. White	2.18	1.28–3.70	0.004	0.74	0.33–1.66	0.468
Ethnicity	Non-Hispanic v Hispanic	1.66	0.97–2.82	0.064	0.74	0.33–1.67	0.467
	Unknown v Hispanic	0.38	0.26–0.56	<0.001	0.72	0.46–1.13	0.153
Disease status	PR v CR	0.92	0.57–1.47	0.724	1.16	0.69–1.97	0.569
	SD v CR	0.90	0.67–1.21	0.489	0.93	0.69–1.25	0.626
	PD v CR	0.88	0.61–1.28	0.512	0.64	0.37–1.08	0.095
Advanced disease	Yes v No	1.24	0.94–1.65	0.133	1.15	0.81–1.63	0.444
ECOG PS	1 v 0	1.99	1.52–2.63	<0.001	1.37	1.00–1.88	0.047
	2–4 v 0	3.28	2.16–4.99	<0.001	1.21	0.76–1.92	0.430
Weight loss	>5% v ≤5%	0.97	0.70–1.34	0.846	0.70	0.48–1.02	0.061
Prior systemic treatment	Yes v No	1.48	1.18–1.86	0.001	1.30	1.04–1.62	0.023
Prior radiotherapy	Yes v No	0.97	0.80–1.20	0.807	0.95	0.75–1.21	0.696
Current treatment	Yes v No	1.05	0.85–1.31	0.647	1.55	1.21–1.98	<0.001
Any counseling service	Yes v No	1.17	0.76–1.82	0.476	1.05	0.72–1.51	0.814
Any support group	Yes v No	0.90	0.61–1.31	0.574	0.85	0.46–1.56	0.598
Medicine currently taken	5–9 v 0–4	1.38	1.09–1.73	0.006	1.11	0.84–1.46	0.474
	≥10 v 0–4	1.73	1.31–2.30	<0.001	0.95	0.66–1.36	0.768
	Unknown v 0–4	1.07	0.69–1.66	0.763	1.08	0.71–1.65	0.713

ECOG PS = Eastern Cooperative Oncology Group performance status; CR = complete response; PR = partial response; SD = stable disease; PD = progressive disease.

Of the 3106 patients, 3080 of them reported a numbness/tingling score at the initial assessment. Of the 3080 patients with numbness/tingling data, 170 patients had missing values for at least one of the covariates, and 2910 patients were included in this regression model.

Of the 3106 patients, 181 patients had missing values for at least one of the covariates, and 2925 patients were included in this regression model.