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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Urology. 2015 Apr 8;85(6):1312–1318. doi: 10.1016/j.urology.2015.02.024

Table 2.

Relative risks of bladder cancer associated with updated LUTS status from latency analysis with 2-year lag and 4-year lag.

LUTS status Case No. Person-Years Age-adjusted RR (95% CI) Multivariate RR (95% CI)3
2-year lag1
No LUTS (ref)5 73 82,570 1.0 1.0
Mild LUTS6 258 207,242 1.14 (0.87, 1.49)4 1.14 (0.87, 1.49)
Moderate LUTS7 133 78,669 1.18 (0.87, 1.58) 1.18 (0.87, 1.59)
Severe LUTS8 12 4,961 1.62 (0.86, 3.03) 1.64 (0.87, 3.08)
p for trend 0.11 0.12
Isolated voiding9 15 9,037 1.25 (0.72, 2.18) 1.18 (0.66, 2.08)
Isolated storage10 55 30,135 1.20 (0.68, 1.70) 1.17 (0.81, 1.69)
Mixed V+S11 26 11,509 1.59 (1.00, 2.52) 1.60 (1.00, 2.56)
All voiding12 41 20,546 1.48 (1.01, 2.16) 1.41 (0.95, 2.11)
All storage13 81 41,644 1.32 (0.97, 1.80) 1.28 (0.92, 1.80)
4-year lag2
No LUTS (ref)5 66 71,607 1.0 1.0
Mild LUTS 6 226 174,585 1.12 (0.84, 1.48) 1.13 (0.85, 1.50)
Moderate LUTS 7 118 63,304 1.24 (0.90, 1.70) 1.24 (0.90, 1.71)
Severe LUTS 8 10 3,988 1.65 (0.83, 3.26) 1.68 (0.84, 3.33)
p for trend 0.04 0.05
Isolated voiding9 13 7,322 1.26 (0.69, 2.31) 1.21 (0.66, 2.23)
Isolated storage10 46 24,055 1.15 (0.78, 1.71) 1.17 (0.79, 1.74)
Mixed V+S11 26 9,236 1.82 (1.14, 2.92) 1.87 (1.16, 3.00)
All voiding12 39 16,558 1.58 (1.05, 2.38) 1.58 (1.04, 2.38)
All storage13 72 33,291 1.33 (0.94, 1.89) 1.35 (0.95, 1.93)
1

Person-time during 1996-2002 was related to the average of 1992 and 1994 LUTS scores; Person-time after 2002 was related to the average of 1998 and 2000 LUTS scores.

2

Person-time during 1998-2004 was related to the average of 1992 and 1994 LUTS scores; Person-time after 2004 was related to the average of 1998 and 2000 LUTS scores.

3

Adjusted for age, cumulative total fluid intake (in quartiles), cumulative intake of fruits and vegetables (4 categories), intake of bacon (3 categories), updated smoking status (current smoker vs nonsmoker), cumulative pack-years of smoking (6 categories), and diabetes status two years before.

4

RR; 95% CI in parentheses (all such values).

5

No LUTS: total AUA-7 score less than or equal to 1.

6

Mild LUTS: total AUA-7 score greater than 1 but less than or equal to 7.

7

Moderate LUTS: total AUA-7 score greater than 7 but less than or equal to 19.

8

Severe LUTS: total AUA-7 score greater than 19.

9

Isolated voiding: voiding subgroup score equal to or higher than 8 and storage subgroup score less than 6.

10

Isolated storage: storage subgroup score equal to or higher than 6 and voiding subgroup score less than 8.

11

Mixed V+S: voiding subgroup score equal to or higher than 8 and storage subgroup score equal to or higher than 6.

12

All voiding: voiding subgroup score equal to or higher than 8.

13

All storage: storage subgroup score equal to or higher than 6.