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. 2015 Jun 25;5:11722. doi: 10.1038/srep11722

Figure 1. Abnormal loading induces mitochondrial superoxide level and selective downregulation of Sod2 in chondrocytes in vivo.

Figure 1

(a) Flow cytometric analyses of superoxide generation in wild-type chondrocytes isolated from tibial plateau at 2 weeks after DMM surgery. Left and right panels indicate findings of DHE and MitoSOX staining, respectively. Sham: sham-surgery, DMM: DMM surgery (n = 5, *P < 0.05, ***P < 0.001 versus sham, Student’s t-test). Error bars show the mean ± s.d. (b) Gene expression of superoxide-degrading enzymes in wild-type chondrocytes isolated from the tibial plateau at 2 weeks after DMM surgery. Sham: sham-surgery, DMM: DMM surgery. Error bars show the mean ± s.d. (n = 3, **P < 0.01 versus sham, n.s.: not significant, Student’s t-test).