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. Author manuscript; available in PMC: 2016 Sep 24.
Published in final edited form as: Brain Res. 2014 Dec 24;1621:170–186. doi: 10.1016/j.brainres.2014.12.026

Fig. 8.

Fig. 8

The inactive isomer of THP prevents deficits in synaptic plasticity during proestrus. (A) Effect of THP isomers as a % of maximal GABA-gated current (GABAMAX), recorded from recombinant α4βδ GABARs expressed in HEK-293 cells (whole cell voltage clamp). n=5 cells/group; *P<0.001 vs. other groups. (B) LTP, CA1 hippocampus (TBS, arrow) on Proestrus PM (Pro-PM), vehicle vs. 3β-OH-THP (30 nM), the inactive isomer of THP. t(9)=6.1, *P=0.0002, n=5–6/group. (C) LTP, Proestrus AM (Pro-AM), vehicle vs. THP (30 nM). t(9)=7.44, *P<0.0001, n=5–6/group.