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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Hepatology. 2015 Feb 27;62(1):220–231. doi: 10.1002/hep.27677

Fig. 2. Activation of FXR signaling increased hepatic expression of LSD1 in an FXR-specific manner.

Fig. 2

(A) WT or FXR-KO mice were treated with GW4064 or vehicle for 3 h and livers were collected for q-RTPCR to measure Lsd1 mRNA (left) or pre-mRNA (right) levels. (B) Expression of hepatic nuclear LSD1 was detected by IB in mice that had been treated with GW4064 for 3 h. (C, D) Mice were fed normal chow or 0.5% CA supplemented chow for 6 h (C) or were fasted overnight and further fasted or refed for 6 h (D). Livers were collected for q-RTPCR. The mean and SEM are plotted and statistical significance was measured using Student’s t-test. *p<0.05 and NS statistically not significant, n=3.