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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Hepatology. 2015 Feb 27;62(1):220–231. doi: 10.1002/hep.27677

Fig. 5. LSD1-mediated epigenomic regulation of BA synthetic and uptake genes also occurs in mouse liver in response to CA feeding.

Fig. 5

(A) Experimental outline. (B) Effects of downregulation of LSD1 on hepatic nuclear levels of LSD1 detected by IB. (C, D) Effects of downregulation of LSD1 on occupancy of SHP and LSD1, and H3K4-me3 levels at Cyp7a1, Cyp8b1, and Ntcp promoters (C), and mRNA levels of these genes (D).