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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Hepatology. 2015 Feb 27;62(1):220–231. doi: 10.1002/hep.27677

Fig. 7. In vivo downregulation of LSD1 leads to impaired transcriptional responses to a high BA load.

Fig. 7

The experimental outline is as described in the Fig. 6 legend. (A) Effects of downregulation of hepatic LSD1 on protein occupancy and histone modification at Cyp7a1, Cyp8b1, and Ntcp promoters. (B, C, E, F) Effects of downregulation of LSD1 on expression of the indicated genes detected by q-RTPCR. The mean and SEM (n=3) are plotted and statistical significance was measured using Student’s t-test. *p<0.05, **p<0.01and NS statistically not significant. (D) Expected changes in liver BA flow in LSD1-downregulated mice challenged with a BA overload based on transcriptional changes are illustrated.