Table 1.

Enzymatic activity and cancer relevant functions of PARPs.

PARP	Other Names	Demonstrated Activity*	Predicted Activity	ADPr Binding Domains	Cancer Related Functions	Cancers to target
1	“PARP” ARTD1	PAR10			DNA Repair14, ERK/ NF-kB signaling118, Heat shock response119	HR deficient Elevated ERK/NF-kB signaling
2	ARTD2	PAR120			DNA Repair120	HR deficient
3	ARTD3	MAR121			DNA Repair122
4	vPARP ARTD4	MAR61
5a	TNKS1 ARTD5	PAR123			Telomere Maintenance124, Wnt Signaling125, Proteasome Regulation126, Stress Granule Assembly17, Cell Division127	Elevated Wnt Signaling Telomerase Dependent Stress Granule Positive Solid Tumors
5b	TNKS2 ARTD6	PAR128			Telomere Maintenance128, Wnt Signaling125	Elevated Wnt Signaling, Telomerase Dependent
6	ARTD17		MAR3		Negative Regulator of Proliferation62	Potential Tumor Suppressive Functions
7	tiPARP ARTD14	MAR64		WWE
8	ARTD16		MAR3
9	BAL1 ARTD9	No automodification activity113	Inactive3	Macro (2)	Cell Migration60	Metastatic Cancers
10	ARTD10	MAR3			Inhibits Myc88 and NF-kB57 signaling Pro-apoptotic91	Potential Tumor Suppressive Functions
11	ARTD11		MAR3	WWE
12	ARTD12	MAR17		WWE	Stress Granule Assembly17	Stress Granule Positive Solid Tumors
13	ZAP ZC3HAV1 ARTD13	No automodification activity3	Inactive3	WWE	Stress Granule Assembly17, miRNA-RISC regulation17, 56	Stress Granule Positive Solid Tumors
14	BAL2 ARTD8	MAR3		Macro (3) WWE	B cell survival102, Cell Migration52, Stress Granule Assembly17	Hematopoeitic malignancies, Metastatic Cancers
15	BAL3 ARTD7	MAR17		Macro (1)	Stress Granule Assembly17	Stress Granule Positive Solid Tumors
16	ARTD15	MAR51, 70			ER Unfolded Protein Response51	UPR dependent

^*Catalytic activity is based on ability of PARPs to automodify when incubated with NAD⁺. PAR: poly(ADP)-ribose; MAR: mono(ADP-ribose); HR: Homologous Recombination; ER: endoplasmic reticulum