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Neurotrophic factors requirement for neurite extension.
A. TF receptors expression in the motor neuron cell line.
B. Five trophic factors expressed/secreted by HUMS cells are required for neurite extension. CM induces extensive long neurite outgrowth in the motor neuron cell line, NSC34, which is inhibited by the simultaneous neutralization with all the 5 Trophic Factors’ antibodies excluding BDNF. Statistically significant. **- P<0.001.
