. 2015 Apr;22(2):61–69. doi: 10.5214/ans.0972.7531.220203

Table 1: Characteristic of studies included in the meta-analysis of the association of IL-6 G174C and G572C gene polymorphism with the risk of ischemic stroke.

S. No	Year	Author	Origin	Ethnicity	Cases/controls	HWE	Matching criteria	Genotyping Method	Variants	M/F	Age[Mean ± S.D]	NOS Star	Source of control
M = Male; F = Female; S.D = Standard Deviation; HWE = Hardy Weinberg Equilibrium; NOS = Newcastle Ottawa Scale; PB = Population Based; HB = Hospital based, PCR-RFLP-Polymerase Chain Reaction-Restriction Fragment Length Polymorphism, RT-PCR-Real Time-Polymerase Chain Reaction.
1.	2010	Tong et al.	China	Asian	748/748	Yes	Age + Sex	Taqman Sequencing	G174C G572C	431/317	61.52 ± 9.68	8/9	PB
1.	2010	Tong et al.	China	Asian	748/748	Yes	Age + Sex	Taqman Sequencing	G174C G572C	431/317	60.61 ± 9.11	8/9	PB
2.	2005	Lalouschek et al.	Austria	Caucasian	404/415	Yes	Smoking	Multiplex PCR	G174C	257/147	53 (49–57)	8/9	PB
2.	2005	Lalouschek et al.	Austria	Caucasian	404/415	Yes	Smoking	Multiplex PCR	G174C	253/162	49 (43–56)	8/9	PB
3.	2004	Flex et al.	Italy	Caucasian	237/223	Yes	Age + Sex	PCR-RFLP	G174C	132/105	76.2 ± 9.4	6/9	HB
3.	2004	Flex et al.	Italy	Caucasian	237/223	Yes	Age + Sex	PCR-RFLP	G174C	107/116	76.1 ± 6.8	6/9	HB
4	2012	Tuttolomondo et al.	Italy	Caucasian	96/48	No	Age	PCR-RFLP	G174C	45/51	71.9 ± 9.75	7/9	HB
4	2012	Tuttolomondo et al.	Italy	Caucasian	96/48	No	Age	PCR-RFLP	G174C	16/32	71.4 ± 7.45	7/9	HB
5.	2008	Banerjee et al.	India	Asian	112/212	Yes	Age + Sex	PCR-RFLP	G174C	72/40	58.6 ± 14.2	7/9	HB
5.	2008	Banerjee et al.	India	Asian	112/212	Yes	Age + Sex	PCR-RFLP	G174C	143/69	57.4 ± 8.8	7/9	HB
6.	2012	Chakraborty et al.	India	Asian	100/120	Yes	Age + Sex	PCR-RFLP	G174C	69/31	54.0 ± 10.9	8/9	PB
6.	2012	Chakraborty et al.	India	Asian	100/120	Yes	Age + Sex	PCR-RFLP	G174C	83/37	52.5 ± 9.8	8/9	PB
7.	2002	Revilla et al.	Spain	Caucasian	82/82	Yes	Age + Sex	PCR-RFLP	G174C	60/22	64.9 ± 9.5	7/9	HB
7.	2002	Revilla et al.	Spain	Caucasian	82/82	Yes	Age + Sex	PCR-RFLP	G174C	55/27	64.8 ± 9.1	7/9	HB
8.	2003	Ma et al.	China	Asian	42/18	Yes	–	–	G174C			8/9	PB
8.	2003	Ma et al.	China	Asian	42/18	Yes	–	–	G174C			8/9	PB
9.	2004	Balding et al.	Ireland	Caucasian	105/389	Yes	Sex	PCR-RFLP	G174C	63/32	69 (35–99)	7/9	PB
9.	2004	Balding et al.	Ireland	Caucasian	105/389	Yes	Sex	PCR-RFLP	G174C	226/163	37.1 (18–65)	7/9	PB
10.	2005	Chamorro et al.	Spain	Caucasian	273/105	Yes	Sex + Same area	PCR-RFLP	G174C	191/82	67.0 ± 10	6/9	HB
10.	2005	Chamorro et al.	Spain	Caucasian	273/105	Yes	Sex + Same area	PCR-RFLP	G174C	62/43	64.0 ± 10	6/9	HB
11.	2006	Li et al.	China	Asian	112/105	No	NA	PCR-RFLP	G174C	NA	NA	8/9	PB
11.	2006	Li et al.	China	Asian	112/105	No	NA	PCR-RFLP	G174C			8/9	PB
12.	2010	Liu et al.	China	Asian	157/163	Yes	NA	PCR-RFLP	G174C	NA	NA	8/9	PB
12.	2010	Liu et al.	China	Asian	157/163	Yes	NA	PCR-RFLP	G174C			8/9	PB
13.	2007	Huang et al.	China	Asian	123/88	Yes	NA	PCR-RFLP	G174C	NA	NA	8/9	PB
13.	2007	Huang et al.	China	Asian	123/88	Yes	NA	PCR-RFLP	G174C			8/9	PB
14.	2007	You et al.	China	Asian	177/112	Yes	NA	PCR-RFLP	G174C	NA	NA	7/9	PB
14.	2007	You et al.	China	Asian	177/112	Yes	NA	PCR-RFLP	G174C			7/9	PB
15.	2014	Xuan et al.	China	Asian	430/461	Yes	Age	Taqman Sequencing	G174C G572C	261/169	45.4 ± 9.5	6/9	HB
15.	2014	Xuan et al.	China	Asian	430/461	Yes	Age	Taqman Sequencing	G174C G572C	253/208	44.8 ± 10.1	6/9	HB
16.	2002	Pola et al.	Italy	Caucasian	119/133	Yes	Age + Sex	PCR-RFLP	G174C	57/62	76.8 ± 8.4	7/9	HB
16.	2002	Pola et al.	Italy	Caucasian	119/133	Yes	Age + Sex	PCR-RFLP	G174C	62/71	76.2 ± 7.1	7/9	HB
17.	2006	Yamada et al.	Japan	Asian	636/2010	Yes	Smoking + BMI	PCR-SSCP	G572C	372/264	67.2 ± 11.1	7/9	HB
17.	2006	Yamada et al.	Japan	Asian	636/2010	Yes	Smoking + BMI	PCR-SSCP	G572C	844/1166	63.0 ± 11.4	7/9	HB