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. 2015 Apr;22(2):108–118. doi: 10.5214/ans.0972.7531.221210

Table 2: Cognitive and behavioural testing in mice and rodent models.

S. No Test Name Measurements Brain function Disease targeted Strain reference
1 Contextual fear conditioning. Fear memory Hippocampal, neocortex and cerebellum functions DMD/BMD mdx 46
Unconditioned fear response. Anxiety
Openfield activity. Spatial learning
Water maze
2 Avoidance Tests Rapid one-trial learning DMD/BMD Mdx mice 47
Passive Avoidance Test Avoidance response
3 Morris Water Maze Spatial learning Hippocampus DMD/BMD Mdx mice/ C57BL/10 control 48
Visual acuity
4 Restraint Freezing response DMD/BMD mdx mice 39
Electrical footshock Fear Conditioning
Elevated plus maze
5 Operant learning task Learning and memory tasks, spatial working memory Hippocampal and forebrain function DMD/BMD mdx 3 cv 40
Delayed spontaneous alternation task in a T-maze
6 The touchscreen testing method. Reward learning, memory, perceptual discrimination, objectplace associative learning, attention, impulsivity, compulsivity, Extinction. Hippocampal functions Schizophrenia Rats & rodents 49
Visual Discrimination and Reversal: The TUNL Task: Working memory and pattern separation. Focus on dentate gyrus and neurogenesis dependent pattern separation
7 The Location Discrimination (LD) task: Visual discrimination neurogenesis dependent pattern separation 50
8 Transverse-pattern task Non-spatial learning Hippocampal function NMDA induced memory impairment. CA1-NR1 knockout mice 51
9 Latent Inhibition selective attention, Hyperactivity ADHD Coloboma mouse model 52
10 Morris Water Maze Spatial learning Visual acuity Hippocampus, neocortex AD Swiss albino mice 53
11 Radial Maze spatial learning Y chromosome induced complexity Inbred mouse strains, NZB and CBArH, 54
12 Environmental Enrichment Increased sensory motor stimulation Down’s Syndrome Ts65Dn mice 55