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. Author manuscript; available in PMC: 2015 Jun 25.
Published in final edited form as: Curr Opin Immunol. 2013 Jan 16;25(1):46–52. doi: 10.1016/j.coi.2012.12.007

Figure 1. CLR control of uptake and degradation of cell corpses.

Figure 1

CLRs regulation of uptake of apoptotic (Mgl1, Lox-1 or DEC-205) or necrotic cells (DEC-205 or DNGR-1). DNGR-1 and LOX-1 promote localisation of cargo to an early endosome compartment. In particular, DNGR-1 sequesters cargo in a poorly degradative early endocytic compartment that favours class I cross-presentation. Mgl1 and DEC-205 primarily deliver cargo to a late endosome-lysosomal compartment, which is best suited for MHC class II presentation.