Table 2.
CYP450 genotype and serum levels of antidepressant as predictors of overall ADR burden
| Antidepressant | Predictor | Number | obs | p value | coeff | SE (robust) | |
|---|---|---|---|---|---|---|---|
| Nortriptyline | CYP2D6 genotype | 251 | 2183 | 0.5638 | −0.133 | 0.229 | |
| CYP2D6; poor metabolisers vs all other genotypes | 251 | 2183 | 0.5527 | −0.321 | 0.541 | ||
| Serum concentration | nortriptyline | 184 | 1890 | 0.8534 | −0.029 | 0.154 | |
| 10-hydroxynortriptyline | 180 | 1847 | 0.7323 | 0.063 | 0.183 | ||
| ratio (10-hydroxynortriptyline: nortriptyline) | 178 | 1832 | 0.1895 | 0.232 | 0.176 | ||
| total (nortriptyline + 10-hydroxynortriptyline) | 178 | 1832 | 0.7975 | 0.044 | 0.170 | ||
| Escitalopram | CYP2C19 genotype | 340 | 3332 | 0.9627 | −0.004 | 0.084 | |
| CYP2C19; poor metabolisers vs all other genotypes | 340 | 3332 | 0.5791 | −0.361 | 0.649 | ||
| Serum concentration | escitalopram | 275 | 2978 | 0.0852 | 0.250 | 0.145 | |
| desmethylcitalopram | 205 | 2242 | 0.1587 | 0.248 | 0.175 | ||
| ratio (desmethylcitalopram: escitalopram) | 204 | 2230 | 0.6945 | −0.066 | 0.167 | ||
| total (escitalopram + desmethylcitalopram) | 204 | 2230 | 0.1155 | 0.260 | 0.165 | ||