Table 3.
The explained variance (Nagelkerke R2) for glaucoma in ANZRAG (1,155 cases and 1,992 controls) and NEIGHBOR (2,131 cases and 2,290 controls) determined by the single nucleotide polymorphisms from the genome-wide association analysis for disc area and cup area
| P-value threshold | number of tested SNPs | Disc area
|
Number of tested SNPs | Cup area
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ANZRAG
|
NEIGHBOR
|
ANZRAG
|
NEIGHBOR
|
|||||||||
| Beta | R2 | P-value | R2 | P-value | Beta | R2 | P-value | R2 | P-value | |||
| <10−8 | 63 | −0.15 | 0.0011 | 1.08 × 10−1 | 0.0007 | 1.25 × 10−1 | 55 | 1.96 | 0.0207 | 4.08 × 10−12 | 0.0316 | <2.00 × 10−16 |
| <10−7 | 85 | −0.14 | 0.0010 | 1.24 × 10−1 | 0.0007 | 1.34 × 10−1 | 87 | 1.82 | 0.0207 | 4.22 × 10−12 | 0.0353 | <2.00 × 10−16 |
| <10−6 | 106 | −0.12 | 0.0009 | 1.52 × 10−1 | 0.0008 | 1.02 × 10−1 | 124 | 1.56 | 0.0179 | 1.23 × 10−10 | 0.0355 | <2.00 × 10−16 |
| <10−5 | 173 | −0.09 | 0.0005 | 2.62 × 10−1 | 0.0014 | 2.95 × 10−2 | 183 | 1.43 | 0.0190 | 3.30 × 10−11 | 0.0348 | <2.00 × 10−16 |
| <10−4 | 340 | −0.04 | 0.0001 | 5.87 × 10−1 | 0.0019 | 1.29 × 10−2 | 428 | 1.09 | 0.0180 | 1.11 × 10−10 | 0.0313 | <2.00 × 10−16 |
| <10−3 | 1,315 | −0.01 | 0.0000 | 9.22 × 10−1 | 0.0034 | 7.72 × 10−4 | 1,410 | 0.88 | 0.0211 | 2.48 × 10−12 | 0.0316 | <2.00 × 10−16 |
| <10−2 | 7,731 | 0.07 | 0.0015 | 6.67 × 10−2 | 0.0040 | 2.85 × 10−4 | 7,782 | 0.49 | 0.0183 | 7.84 ×10−11 | 0.0284 | <2.00 × 10−16 |
| <0.1 | 56,542 | 0.07 | 0.0055 | 3.71 × 10−4 | 0.0038 | 3.87 × 10−4 | 58,133 | 0.21 | 0.0151 | 3.42 × 10−9 | 0.0165 | 1.52 × 10−13 |
| <0.2 | 106,818 | 0.05 | 0.0048 | 8.39 × 10−4 | 0.0049 | 5.73 × 10−5 | 108,666 | 0.15 | 0.0132 | 3.14 × 10−8 | 0.0149 | 2.44 × 10−12 |
| <0.3 | 155,892 | 0.04 | 0.0038 | 2.94 × 10−3 | 0.0054 | 2.54 × 10−5 | 157,742 | 0.13 | 0.0114 | 2.94 × 10−7 | 0.0142 | 7.10 × 10−12 |
| <0.4 | 204,028 | 0.04 | 0.0041 | 2.20 × 10−3 | 0.0053 | 2.76 × 10−5 | 205,288 | 0.11 | 0.0107 | 6.76 × 10−7 | 0.0137 | 1.87 × 10−11 |
| <0.5 | 252,003 | 0.04 | 0.0042 | 1.97 × 10−3 | 0.0057 | 1.42 × 10−5 | 252,595 | 0.11 | 0.0110 | 4.51 × 10−7 | 0.0127 | 1.01 × 10−10 |
| <0.6 | 299,085 | 0.04 | 0.0042 | 1.93 × 10−3 | 0.0059 | 1.05 × 10−5 | 299,291 | 0.11 | 0.0112 | 3.60 × 10−7 | 0.0123 | 1.83 × 10−10 |
| <0.7 | 345,745 | 0.04 | 0.0042 | 1.96 × 10−3 | 0.0058 | 1.30 × 10−5 | 346,007 | 0.11 | 0.0110 | 4.82 × 10−7 | 0.0126 | 1.19 × 10−10 |
| <0.8 | 392,318 | 0.04 | 0.0042 | 1.83 × 10−3 | 0.0058 | 1.19 × 10−5 | 392,623 | 0.11 | 0.0111 | 4.26 × 10−7 | 0.0127 | 9.37 × 10−11 |
| <0.9 | 438,618 | 0.04 | 0.0042 | 1.96 × 10−3 | 0.0058 | 1.15 × 10−5 | 438,802 | 0.11 | 0.0109 | 4.96 × 10−7 | 0.0125 | 1.23 × 10−10 |
| <1.0 | 484,974 | 0.04 | 0.0041 | 2.04 × 10−3 | 0.0058 | 1.15 × 10−5 | 484,974 | 0.11 | 0.0110 | 4.73 × 10−7 | 0.0126 | 1.19 × 10−10 |