| A. Definite criteria |
| Positive culture, PCR, or immunochemistry of a cardiac valve |
| B. Major criteria |
| Microbiology: positive culture or PCR of the blood or an emboli
or serology with IgG I antibodies ≥6,400 |
| Evidence of endocardial involvement: |
| Echocardiogram positive for IE: oscillating intra-cardiac
mass on valve or supporting structure, in the path of
regurgitant jets, or on implanted material in the absence of
an alternative anatomic explanation; or abscess; or new
partial dehiscence of prosthetic vale; or new valvular
regurgitation (worsening or changing of pre-existent murmur
not sufficient) |
| PET scan showing a specific valve fixation and mycotic
aneurysm |
| C. Minor criteria |
| Predisposing heart condition (known or found on
echocardiograph) |
| Fever, temperature >38°C |
| Vascular phenomena, major arterial emboli, septic pulmonary
infarcts, mycotic aneurysm (see at PET scan), intracranial
hemorrhage, conjunctival hemorrhages, and Janeway lesions |
| Immunologic phenomena: glomerulonephritis, Osle nodes,
Roth spots, or rheumatoid factor |
| Serologic evidence: IgG I antibodies ≥800 <6,400 |
| Diagnosis definite |
| 1. 1A criterion |
| 2. 2B criterion |
| 3. 1B, and 3C criterion |
| Diagnosis possible |
| 1. 1B criterion, 2C criteria (including microbiology evidence,
and cardiac predisposition) |
2. 3C criteria (including positive serology, and cardiac
predisposition)
|
| Q fever vascular infection |
| A. Definite criteria |
| Positive culture, PCR, or immunochemistry of an arterial
sample (prosthesis or aneurysm) or a periarterial abscess or a
spondylodiscitis linked to aorta |
| B. Major criteria |
| Microbiology: positive culture or PCR of the blood or an emboli
or serology with IgG I antibodies ≥6,400 |
| Evidence of vascular involvement
CT scan: aneurysm or vascular prosthesis + periarterial
abscess, fistula, or spondylodiscitis
PET scan: specific fixation on an aneurysm or vascular
prosthesis |
| C. Minor criteria |
| Serological IgG I ≥800 <6,400 |
| Fever, temperature >38°C |
| Emboli |
| Underlying vascular predisposition (aneurysm or vascular
prosthesis) |
| Diagnosis definite |
| 1. 1A criterion |
| 2. 2B criterion |
| 3. 1B and 2C criterion (including microbiology findings and
vascular predisposition) |
| Diagnosis possible |
Vascular predisposition, serological evidence and fever or
emboli
|
| *Source (16). IE, infective endocarditis; PET, positron emission tomography; IFA, immunofluorescence assay; CT, computed tomography. |
