Effects of ORAI1, ORAI2, and ORAI 3 tandem shRNA expression on OT- and CPA-stimulated SRCE and ER refilling in PHM1-41 cells are shown. A) Effects of ORAI1–ORAI3 mRNA knockdown on OT-stimulated responses. Data are presented as described in the legend to Figure 8 (control adenovirus (Rsh, blue lines); ORAI1–ORAI3 shRNA (O123sh, orange lines); n = 10–11). B) Effects of ORAI1, ORAI2, and ORAI3 mRNA knockdown on CPA-stimulated responses are shown. Data are presented as described in the legend to A (n = 16–17).