Table 1.
Univariate and multivariate analysis of elafin-positive cells in breast cancer patients
| A. Univariate analysis, breast cancer (n = 793) | ||||
|---|---|---|---|---|
| Factors | Elafin negative (n = 311) | Elafin positive (n = 482) | p-value | |
| Age of diagnosis, year | 0.02 | |||
| Mean | 55.5 | 53.5 | ||
| Median (range) | 55 (26–86) | 52 (25–87) | ||
| Stage | <0.0001 | |||
| I | 120 (38.7) | 115 (24.0) | ||
| IIA | 128 (41.3) | 241 (50.2) | ||
| IIB | 62 (20.0) | 124 (25.8) | ||
| Unknown | 1 | 2 | ||
| ER | <0.0001 | |||
| Positive | 266 (85.5) | 280 (58.3) | ||
| Negative | 45 (14.5) | 200 (41.7) | ||
| Unknown | 0 | 2 | ||
| PR | <0.0001 | |||
| Positive | 218 (70.1) | 236 (49.2) | ||
| Negative | 93 (29.9) | 244 (50.8) | ||
| Unknown | 0 | 2 | ||
| HER-2 | 0.013 | |||
| Positive | 42 (13.5) | 98 (20.4) | ||
| Negative | 269 (86.5) | 383 (79.6) | ||
| Unknown | 0 | 1 | ||
| Grade | <0.0001 | |||
| I | 41 (14.2) | 31 (6.8) | ||
| II | 186 (64.6) | 197 (43.5) | ||
| III | 61 (21.2) | 225 (49.7) | ||
| Unknown | 23 | 29 | ||
| Tumor subtype | <0.0001 | |||
| Luminal A | 185 (61.9) | 158 (33.1) | ||
| Luminal B | 45 (15.1) | 94 (19.8) | ||
| Her2 positive | 42 (14.0) | 98 (20.7) | ||
| Triple negative | 27 (9.0) | 125 (26.4) | ||
| Unknown | 12 | 7 | ||
| Recurrence | <0.0001 | |||
| No | 250 (80.9) | 298 (62.3) | ||
| Yes | 59 (19.1) | 180 (37.7) | ||
| Unknown | 2 | 4 | ||
| B. Multivariate Cox proportional hazards analysis of clinicopathologic variables’ influence on breast cancer RFS in whole cohort (n = 793) | ||||
| Factor | HR | Se | P | 95% CI |
| Stage | ||||
| I | referent | |||
| IIA | 1.67 | 0.31 | 0.005 | 1.17-2.39 |
| IIB | 2.41 | 0.47 | <0.0001 | 1.65-3.52 |
| Age | 0.98 | 0.01 | <0.0001 | 0.97-0.99 |
| Elafin Positive | 1.94 | 0.3 | <0.0001 | 1.44-2.62 |