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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Mol Immunol. 2015 Feb 28;65(2):336–349. doi: 10.1016/j.molimm.2015.02.012

Figure 5. An IQGAP1 complex tethers F-actin to microtubules.

Figure 5

IQGAP1 plays an important role in linking polymerized actin filaments (F-actin) with microtubules. A) The RGCT domain of IQGAP1 links F-actin to plus-end microtubules at the leading edge membrane via a complex including Axin, APC, CLIP170 and Clasp2. GSK-3β acts as a negative regulator of this complex by phosphorylating Clasp2 which causes it to disassociate from IQGAP1 leading to a reduction in cell movement. B) Although the role of IQGAP1 in the formation and function of the MTOC is not well understood, its interaction with Axin and APC may facilitate the organization and multimerization of γ-tubulin molecules that form the core of the centrosome and MTOC. IQGAP1 has also been to localize to the cytoplasmic face of the nuclear envelope, potentially promoting cell cycle-associated assembly and disruption of nuclear envelope