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. Author manuscript; available in PMC: 2015 Jun 25.
Published in final edited form as: Curr Protoc Hum Genet. 2013 Jan;0 7:Unit7.20. doi: 10.1002/0471142905.hg0720s76

Figure 7.20.4.

Figure 7.20.4

The PolyPhen-2 Batch Query Web page allows submitting large number of variants for analysis in a single operation. Type or paste your variants into the Batch Query text input area (one variant per line) or upload a text file listing variants using Upload batch file text box (locate the file using the Browse button). If you enter your e-mail address into the corresponding text box, you will be notified via e-mail when your query completes. To analyze protein variants in nonstandard or unannotated proteins, you can upload your own protein sequences in FASTA format using the Upload FASTA file text box. Genomic variants are also supported; see the Sample Batch panel for the various input format examples. Do not forget to select the genome assembly version matching your genomic SNP data under Advanced Options; default assembly version used is GRCh37/UCSC hg19.