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5-Substituted pyridine-3-carboxylic acids (2a–f) obtained and evaluated as potential substrates for the chemoenzymatic synthesis designed to produce novel pyridinium substituted NAADP derivatives.
| Structure | Cmpd | Substituent | Base-exchange product detected |
|---|---|---|---|
 |
2a | -OH | yes |
| 2b | -Br | no | |
| 2c | -NH-COCH3 | yes | |
| 2d | -SCH3 | yes | |
| 2f | -CH2-CH2-C6H5 | no | |
| 6 | -CH2-CH2-CH2-NH-COCH3 | yes | |
| 11 | -CH2-CH2-CH2-NH-t-Boc | yes | |
| 12 | -CH2-CH2-CH2-NH3+ | yes | |
| 15 | -CH2-CH2-CH2-OH | yes | |
| 18 | -CH2-CH2-CH2-N3 | yes | |
