Table 1. Incidence Rates and Hazard Ratios (HR) for Event-Free Survival (EFS) and Overall Survival (OS); (N=102).
| N | Number (%) of relapses or deaths | Incidence Rates x 1000 (EFS) |
HR (P) |
Number (%) of deaths | Incidence Rates × 1000 (OS) |
HR (P) |
|
|---|---|---|---|---|---|---|---|
| Age | |||||||
| ≥ 18 months | 44 | 25 (56.8%) | 19.4 (13.1-28.7) | 2.45 (P=0.017) | 19 (43.2%) | 12.3 (7.9-19.3) | 3.2 (P=0.006) |
| < 18 months (reference) | 58 | 16 (27.6%) | 7.9 (4.8-12.9) | 9 (15.5%) | 3.9 (2.0-7.5) | ||
| Stage | |||||||
| 4 | 31 | 20 (64.5%) | 19.2 (12.4-29.8) | 2.1 (P=0.004) | 18 (58.1%) | 15.1 (9.5-24.0) | 4.0 (P<0.0001) |
| 1, 2, 3, 4s (reference) | 71 | 21 (29.6%) | 9.2 (6.0-14.2) | 10 (14.1%) | 3.7 (2.0-7.0) | ||
| MYCN status | |||||||
| Amplified | 44 | 25 (56.8%) | 22.6 (15.3-33.4) | 3.1 (P=0.004) | 21 (47.7%) | 17.1 (11.2-26.2) | 6.4 (P<0.0001) |
| Not amplified (reference) | 58 | 16 (27.6%) | 7.25 (4.4-11.8) | 7 (12.1%) | 2.7 (1.3-5.6) | ||
| Ploidy | |||||||
| Diploid | 49 | 26 (53.1%) | 16.6 (11.3-24.4) | 1.9 (P=0.029) | 17 (34.7%) | 9.0 (5.6-14.5) | 1.6 (P=0.10) |
| Hyperdiploid (reference) | 53 | 15 (28.3%) | 8.6 (5.2-14.2) | 11 (20.7%) | 5.6 (3.1-10.1) | ||
| Histology | |||||||
| Unfavorable histology | 50 | 30 (60.0%) | 19.3 (13.5-27.7) | 3.1 (P=0.001) | 24 (48.0%) | 13.2 (8.8-19.6) | 6.7 (P<0.0001) |
| Favorable histology (reference) | 52 | 11 (21.1%) | 6.2 (3.45-11.3) | 4 (7.7%) | 2.0 (0.7-5.2) | ||
| Risk Group (N=86) | |||||||
| High/Intermediate | 58 | 33 (56.9%) | 19.4 (13.5-27.7) | 4.8 (P=0.002) | 27 (46.6%) | 13.8 (9.5-20.1) | 15.2 (P=0.0003) |
| Low (reference) | 28 | 4 (14.3%) | 4.0 (1.5-10.7) | 1 (3.6%) | 0.9 (0.1-6.5) | ||
| Telomere length | |||||||
| Long | 46 | 27 (58.7%) | 22.7 (15.6-33.2) | 7.0 (P<0.0001) | 19 (41.3%) | 12.2 (7.8-19.1) | 7.8 (P=0.0006) |
| Normal | 13 | 8 (61.5%) | 27.75 (13.9-55.5) | 8.5 | 6 (46.1%) | 16.0 (7.2-35.6) | 10.2 |
| Short (reference) | 43 | 6 (13.9%) | 3.26 (1.5-7.3) | 3 (7.0%) | 1.6 (0.5-4.8) | ||
| h-TERT (N=99) | |||||||
| > 0.398 (> 0.205) | 31 | 21 (67.7%) | 26.1 (17.0-40.1) | 3.8 (P<0.0001) | 23/61 (37.7%) | 10.6 (7.0-16.0) | 5.9 (P=0.003) |
| ≤ 0.398 (≤ 0.205) | 68 | 17 (25.0%) | 6.8 (4.3-11.0) | 3/38 (7.9%) | 1.8 (0.6-5.7) | ||
| ALT mechanism | |||||||
| Positive | 60 | 28 (46.7%) | 15.1 (10.4-21.9) | 1.7 (P=0.11) | 21 (35.0%) | 9.5 (6.2-14.5) | 2.2 (P=0.035) |
| Negative | 42 | 13 (30.9%) | 8.9 (5.2-15.3) | 7 (16.7%) | 4.3 (2.0-9.0) |
P values refer to the Log-Rank test.