Figure 7. miR-145-mediated calcitriol inhibited expression of cell cycle proteins.

(A) Western blot analyses in SGC-7901 cells after treatment of 1,25(OH)2D3 or transfection of miR-145 inhibitor. (B) Proposed model for miR-145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in GC cells.