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. 2015 Mar 8;6(10):7828–7837. doi: 10.18632/oncotarget.3488

Fig.5. Knockdown of CD44 induced the MET in SMMC-7721 and MHCC97-H cells by repressing the ERK/Snail pathway.

Fig.5

(A) qRT-PCR analysis of the mRNA expression of transcription factors that predominantly drive EMT in SMMC-7721 and MHCC97-H cells transfected with shRNA of CD44 or NC. (B) Quantification of Western blot showed different phospho-ERK and Snail expression in SMMC-7721 and MHCC97-H cells with or without CD44-knockdown. (C) The expression of CD44, ERK, p-ERK and Snail was detected in metastatic lung samples by immunohistochemical staining and shown with a 400× field.