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. 2015 Mar 10;6(10):8071–8088. doi: 10.18632/oncotarget.3513

Figure 10. A schematic model of network prediction and experimental validation of a novel AMPK/ZIPK activator BL-AD008 in cervical cancer.

Figure 10

(A) We systematically constructed the global protein-protein interaction (PPI) network and integrated four different biological evidence to predict apoptosis-related protein connections by the Naïve Bayesian model; (B) Utilizing the Naïve Bayesian model and four golden standards, we identified some key apoptotic kinase targets, such as AMPK and ZIPK in cancer; (C) We screened many candidate compounds, synthesized some compounds and eventually designed a novel dual-target activator (BL-AD008) that induced the death-receptor and mitochondrial apoptosis, which was affected by AMPK and ZIPK in cervical cancer in vitro and in vivo.