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. 2015 Mar 10;6(10):8071–8088. doi: 10.18632/oncotarget.3513

Figure 3. Chemical structure modification strategies of from compound A1 to BL-AD008.

Figure 3

The structural modification was mainly focused on C-3 position of indole ring using bioisostere replacement strategy. The synthesis process of candidate compounds (AD001-BL-AD008) is described as follows. The high degree of symmetry in these molecules enabled facile confirmation by NMR technique.