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. 2015 Mar 10;6(10):8071–8088. doi: 10.18632/oncotarget.3513

Figure 8. Anti-tumor effects of BL-AD008 in vivo.

Figure 8

(A) Anti-tumor activities of BL-AD008 and its toxicity. The treatments began on day 1 after grouping (day 0), including vehicle, low dose of BL-AD008 10 mg/kg once a day, median dose of BL-AD008 20 mg/kg once a day and high dose of BL-AD008 40 mg/kg once a day for 10 days. Points, mean of tumors; bars, standard deviation. *, P <0.05; **, P <0.01; ***, P<0.001 compared with vehicle-treated tumors. (B) The inhibitory rate of tumor. Representative tumors from mice after vehicle and BL-AD008 treatment. (C) (a) Immunohistochemistry of proliferative marker KI67. Ki-67 expression in representative tumor section of a control mouse and a mouse of the median dose group (×100 magnification). (b) TUNEL immunohistochemistry. TUNEL immunohistochemistry in representative tumor section of a control mouse and a mouse of the median dose group (×100 magnification).