Table 1. Radiosensitivity of MSC.
The table shows the percentage of cycling (Ki67+), apoptotic and senescent cells six hours after X-ray treatment (40, 160, 640 and 2000 mGy). Table reports also clonogenic property of MSC, that was evaluated 15 days post-irradiation with CFU assay. Data are expressed with standard deviation (n = 3, *p < 0.05, **p < 0.01).
Ki67+ | Apoptotic | Senescent | CFU | |
---|---|---|---|---|
0 mGy | 28.8 ± 4.3% | 3.6 ± 0.5% | 16.8 ± 2.1% | 360 ± 25 |
40 mGy | 20.3 ± 2.8% | 6.9 ± 0.9% * | 25.6 ± 3.2% * | 218 ± 10 * |
160 mGy | 23.6 ± 3.3% | 5.2 ± 0.7% * | 31.1 ± 4.3% * | 206 ± 11 * |
640 mGy | 19.6 ± 3.5% | 6.8 ± 0.8% * | 36.3 ± 4.7%** | 225 ± 13 * |
2000 mGy | 21.9 ± 3.7% | 6.8 ± 0.9% * | 40.0 ± 5.6% ** | 100 ± 4 ** |