Table 1. Summary of the most relevant results of the immunohistochemical analyses: number of analyzed specimens is indicated in the table: 88 gastrointestinal NEN specimens were stained for FOXM1, 49 and 36 pancreatic and gastrointestinal cases were analyzed for survivin and STAT3, respectively.

Lower numbers in the metastatic status analyses resulted from 3 cases with unknown status. All markers could be associated with metastatic status, and FOXM1 and nuclear survivin could be significantly linked to differentiation. FOXM1 further significantly correlated with survivin and STAT3 high nuclear staining.

Parameters	FOXM1 expression	Nuclear STAT3	Nuclear survivin	Differentiation	Metastatic status
FOXM1 expression		N=36 p=0.001*	N=49 p=0.030*	N=88 p=0.026*°	N=85 p=0.007*°
Nuclear STAT3	° assessed only in gastrointestinal NENs * univarite analysis		N.D.	N=36 not sig.*	N=36 p=0.007* p=0.011**
Nuclear survivin	**multivariate analysis			N=49 p=0.000*	N=46 p=0.000*