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. Author manuscript; available in PMC: 2015 Jun 25.
Published in final edited form as: Methods Enzymol. 2009;459:165–186. doi: 10.1016/S0076-6879(09)04608-4

Figure 8.1.

Figure 8.1

Modular organization of type I polyketide synthases (PKSs). (A) A prototypical type I PKS module contains the cognate ATdomain and other domains. (B) An AT-less type I PKS module lacks the cognate AT domain but often contains a short segment of remnant AT residues. (C) The remnant ATsegment lacks critical catalytic motifs (GHSxG and AFHS) and is therefore catalytically inactive, but may serve as a docking domain mediating the interactions between the discrete AT (LnmG) and AT-less PKS modules in LnmI and LnmJ (Tang et al., 2004).