(a).

#	Upregulation: GO processes in common versus MCF7, SKBR3, and HCC1937 (130 genes)	p value	FDR
1	Single-organism cellular process	1.586E − 10	4.679E − 07
	SMURF, FTS, ATF-4, AP-3 sigma subunits, SAT-1, Tenascin-C, GLSL, COUP-TFII, GCR-beta, SLIT2, SLFN5, TRUNDD(TNFRSF10D), MCT1 (SLC16A1), Neuropilin-1, RRN3, GLSK, SMAD6, FoxD1, and NIP3
2	Response to organic cyclic compound	3.170E − 10	4.679E − 07
	Tenascin-C, COUP-TFII, GCR-beta, SLIT2, MCT1 (SLC16A1), SMAD6, TIMP3, MKP-3, MKP-1, Lysyl oxidase, Adipophilin, COUP-TFI, Stromelysin-1, SLIT3, Stanniocalcin 2, and VEGF-A
3	Single-organism process	7.615E − 10	6.297E − 07
	SMURF, FTS, MOXD1, ATF-4, AP-3 sigma subunits, SAT-1, Tenascin-C, GLSL, COUP-TFII, GCR-beta, SLIT2, SLFN5, TRUNDD(TNFRSF10D), MCT1 (SLC16A1), Neuropilin-1, RRN3, GLSK, SMAD6, and TIMP3
4	Response to endogenous stimulus	8.532E − 10	6.297E − 07
	SMURF, AP-3 sigma subunits, Tenascin-C, COUP-TFII, GCR-beta, SLIT2, SMAD6, TIMP3, PINCH, Connexin 43, SMURF2, GCR-alpha, PDGF-C, MKP-1, Lysyl oxidase, Stromelysin-1, SLIT3, and VEGF-A
5	Organic anion transport	2.208E − 09	1.304E − 06
	SAT-1, GLSL, MCT1 (SLC16A1), GLSK, MCT4, CAT-1 (SLC7A1), Connexin 43, GLUT3, Adipophilin, SLC25A4, SLC38A1, Carbonic anhydrase XII, SLC38A2, SLC27A3, CAT-3, SLC7A5, and ANT
#	Upregulation: metabolic networks in common versus MCF7, SKBR3, and HCC1937 (130 genes)	p value	FDR
1	Carbohydrate metabolism_glycolysis, glycogenesis, and glucose transport	9.568E − 06	4.497E − 04
	PFKP, GLUT3, ALDOC, ENO2, ALDOA, and ENO
2	Carbohydrate metabolism_sucrose metabolism and transport	4.596E − 05	7.525E − 04
	COUP-TFII, GLUT3, COUP-TFI, Glycogen phosphorylase, and PYGL
3	(L)-Proline pathways and transport	4.803E − 05	7.525E − 04
	CAT-1 (SLC7A1), Glycogen phosphorylase, SLC38A2, CAT-3, SLC7A5
4	L-Serine pathways and transport	1.369E − 04	1.538E − 03
	CAT-1 (SLC7A1), SLC38A1, SLC38A2, CAT-3, and SLC7A5
5	(S)-Citrulline pathway	1.636E − 04	1.538E − 03
	CAT-1 (SLC7A1), Glycogen phosphorylase, CAT-3, and SLC7A5