Table 1.

Results from focal cryotherapy studies mentioning post-treatment histological outcomes

Study	Total number of patients	Treatment modality	Biopsy method for initial diagnosis	Protocol or for-cause biopsy method	Number of patients with a positive post-procedural biopsy/total number of biopsied patients	Biopsy significance	Subsequent treatment
Bargawi et al. [65]	62	Cryo	Template mapping	Protocol 12-month TRUS biopsy	12/62 (19 %) 1/12 bilateral 7/12 ipsilateral 4/12 contralateral side	7/8 NS ipsilateral 3/4 NS contra	AS (5) Redo cryo (5) RRP (2)
Bahn et al. [23]	73	Cryo	Doppler TRUS	Protocol and for cause 6- to 12-month TRUS biopsy	12/48 (25 %) 1/12–ipsilateral 11/12 contralateral side	1/1 NS ipsilateral 9/11 NS contralateral	AS (8) Redo cryo (1) brachy (1) ADT (1)
Ward and Jones [3]	1149	Cryo	NA	For cause TRUS biopsy	42/162 (26 %)	NA	NA
Truesdale et al. [24]	77	Cryo	TRUS	For cause TRUS biopsy	10/22 (45 %) 2/10 ipsilateral 7/10 contralateral 1/10 bilateral	NA	NA
Lambert et al. [25]	25	Cryo	TRUS	For cause or PSA nadir <50 % TRUS biopsy	3/7 (43 %) 1/3 ipsilateral 2/3 contralateral	3/3 NS	Redo cryo (3)
Ellis et al. [26]	60	Cryo	NA	Protocol 12-month TRUS biopsy	14/35 (40 %) 1/14 ipsilateral 13/14 contralateral	NA	Redo cryo (12) Lost to FU (1)
Onik et al. [27]	55	Cryo	Template mapping	For cause and protocol 12-month TRUS Biopsy	Protocol 0/26 For cause 4/4 in untreated portion of gland	NA	Redo cryo (4)
Bahn et al. [27]	31	Cryo	Doppler TRUS	Protocol 6-month TRUS biopsy	1/25 (4 %) 1/1 in untreated portion of gland	NA	Redo cryo (4)

Cryo cryotherapy, TRUS transrectal ultrasound-guided biopsy, NA not available, NS non-significant, ADT androgen deprivation therapy, AS active surveillance