Table 2.

Results from focal HIFU studies mentioning post-treatment histological outcomes

Study	Total number of patients	Treatment modality	Biopsy method for initial diagnosis	Protocol or for-cause biopsy method	Number of patients with a positive post-procedural biopsy/total number of biopsied patients	Biopsy significance	Subsequent treatment
Muto et al. [29]	29	HIFU	TRUS	Protocol 6–12 months TRUS	3/28 at 6 months 4/17 at 12 months	NA	ADT
Fegoun et al. [30]	12	HIFU	NA	Protocol 12 months TRUS	1/12	1/1 NS	Redo HIFU (1)
Ahmed et al. [14]	20	HIFU	Template mapping	Protocol 6 months mpMRI + TRUS targeted of treated side only	2/19 ipsilateral	2/2 NS	AS (1) Redo HIFU (1)
Ahmed et al. [31]	41	HIFU	Template mapping	Protocol 6 months mpMRI + TRUS targeted of treated side only	9/39 ipsilateral	6/9 NS	AS (5) Redo HIFU (4)
Dickinson et al. [32]	88	HIFU	NA	For cause mpMRI + TRUS targeted	20/72 ipsilateral	10/20 NS	NA
Velthoven et al. [33]	27	HIFU	TRUS + concordance with mpMRI lesion 2 months after biopsy	For cause (rising PSA)	3/5 contralateral	3/3 contralateral	Contra-lateral HIFU (3)

HIFU high-intensity focused ultrasound, TRUS transrectal ultrasound-guided biopsy, NA not available, NS non-significant, ADT androgen deprivation therapy, AS active surveillance