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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Clin Pharmacol Ther. 2014 Jul 28;96(5):589–598. doi: 10.1038/clpt.2014.158

Figure 3. Simulated DILI responses in human and rat virtual populations (SimPops) at specified troglitazone (TGZ) dose levels.

Figure 3

Predicted maximum hepatic accumulation of CDCA and LCA species and DILI responses (i.e., minimum hepatic ATP, minimum viable liver mass, maximum serum ALT) post-dose in human SimPops at oral doses of 200 (green triangle), 400 (blue circle), or 600 (red diamond) mg/day TGZ for 6months (A), and rat SimPops at oral doses of 5 (blue circle) or 25 (red diamond) mg/kg/day for 6months (B).