Table 1.
Traits and diseases analyzed in this work. “# Pubs” is number of distinct GWAS publications used in this study. “# Loci” gives the number of loci found after mapping the associated SNPs to non-redundant genomic windows. “# PF combinations” is the number of unique prix fixe subnetworks that can be derived from the associated loci and their constituent genes. “ALL” is acute lymphoblastic leukemia, “CLL” is chronic lymphocytic leukemia, “IBD” is irritable bowel disease. Full details of all GWA studies (including all associated SNPs) are available in the Supplementary Files.
| Trait group | Trait | # Pubs | # Loci | # PF combinations |
|---|---|---|---|---|
| Cancers | ALL | 7 | 44 | 2.4 × 108 |
| Breast cancer | 1 | 58 | 7.5 × 1012 | |
| CL | 5 | 23 | 1.8 ×107 | |
| Colorectal cancer | 13 | 36 | 1.7 × 1010 | |
| Gastric cancer | 3 | 7 | 1.7 × 103 | |
| Glioma | 4 | 8 | 2.6 × 102 | |
| Lung cancer | 18 | 29 | 2.6 × 1012 | |
| Ovarian cancer | 4 | 11 | 8.7 × 104 | |
| Pancreatic cancer | 4 | 31 | 1.9 × 107 | |
| Prostate cancer | 19 | 73 | 7.8 × 1028 | |
| Auto-immune diseases | Type 1 diabetes | 1 | 38 | 9.9 × 1019 |
| Multiple sclerosis | 1 | 75 | 5.7 × 1035 | |
| Crohn’s disease | 1 | 70 | 6.7 × 1034 | |
| Uncerative colitis | 1 | 47 | 1.1 × 1021 | |
| IBD | 1 | 110 | 1.3 × 1053 | |
| Cardiovascular traits | Cholesterol, total | 1 | 52 | 1.4 × 1024 |
| HDL cholesterol | 1 | 47 | 7.3 × 1019 | |
| LDL cholesterol | 1 | 37 | 2.0 × 1018 | |
| Triglycerides | 1 | 32 | 6.1 × 1015 | |
| QT interval | 1 | 27 | 7.3 × 105 | |
| Metabolic traits | Height | 1 | 183 | 1.7 × 1073 |
| Type 2 diabetes | 1 | 26 | 2.2 × 108 | |
| Cognition | Cognitive performance (1) | 1 | 57 | 5.7 × 1012 |
| Cognitive performance (2) | 1 | 53 | 3.2 × 109 |