Table 2.
Ten most significant gene sets enriched in PC1 correlating genes. Tables a and b are subsets of gene sets that were significantly (FDR q-value < 1 %) enriched in PC1 correlating genes by PC-GSEA (for full data, see Additional file 10: Table S7). (a) Gene sets in positively correlated genes, which were upregulated in SGs, and (b) gene sets in negatively correlated genes, which were upregulated in KCs and HaCaTs. SIZE is number of genes belonging the gene set. NES is normalized enrichment score
| Name | SIZE | NES | FDR q-val |
|---|---|---|---|
| (a) | |||
| PEREZ_TP53_AND_TP63_TARGETS | 198 | 2.967 | 0 |
| SMID_BREAST_CANCER_NORMAL_LIKE_UP | 449 | 2.908 | 0 |
| BOQUEST_STEM_CELL_CULTURED_VS_FRESH_DN | 31 | 2.774 | 0 |
| KRAS.LUNG_UP.V1_DN | 128 | 2.774 | 0 |
| ABATES_COLORECTAL_ADENOMA_DN | 248 | 2.760 | 0 |
| WU_SILENCED_BY_METHYLATION_IN_BLADDER_CANCER | 53 | 2.758 | 0 |
| PEREZ_TP63_TARGETS | 334 | 2.742 | 0 |
| WINNEPENNINCKX_MELANOMA_METASTASIS_DN | 46 | 2.735 | 0 |
| KEGG_ASTHMA | 23 | 2.689 | 0 |
| KEGG_ALLOGRAFT_REJECTION | 33 | 2.663 | 0 |
| (b) | |||
| YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13 | 172 | 3.060 | 0 |
| MOOTHA_VOXPHOS | 86 | 3.038 | 0 |
| WONG_EMBRYONIC_STEM_CELL_CORE | 332 | 3.028 | 0 |
| REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTH ESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_ BY_UNCOUPLING_PROTEINS_ | 81 | 3.016 | 0 |
| FOURNIER_ACINAR_DEVELOPMENT_LATE_2 | 276 | 3.005 | 0 |
| KEGG_OXIDATIVE_PHOSPHORYLATION | 111 | 2.954 | 0 |
| PENG_LEUCINE_DEPRIVATION_DN | 186 | 2.947 | 0 |
| GSE22886_UNSTIM_VS_IL15_STIM_NKCELL_DN | 199 | 2.947 | 0 |
| WONG_MITOCHONDRIA_GENE_MODULE | 216 | 2.943 | 0 |
| REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | 65 | 2.924 | 0 |