Table 7.
Significant gene sets enriched in PC3 correlating genes. Tables a, b and c are subsets of gene sets significantly (FDR q-value < 1 %) enriched in PC3 correlating genes by PC-GSEA (for full data, see Additional file 10: Table S7). (a) Table is a subset of the ten (out of 30) gene sets most significantly enriched in the positively correlating genes, which were upregulated in LKCs. (b) Table is cell cycle associated gene sets significantly enriched in the negatively correlating genes, which were upregulated in HaCaTs. (c) Table is miRNA-target gene sets significantly enriched in PC3 negatively correlating genes. SIZE is number of genes belonging the gene set. NES is normalized enrichment score
| Name | SIZE | NES | FDR q-val |
|---|---|---|---|
| (a) | |||
| REACTOME_OLFACTORY_SIGNALING_PATHWAY | 36 | 2.967 | 0 |
| DAZARD_UV_RESPONSE_CLUSTER_G28 | 20 | 2.908 | 0 |
| DAZARD_UV_RESPONSE_CLUSTER_G24 | 27 | 2.774 | 0 |
| PID_CONE_PATHWAY | 16 | 2.774 | 0 |
| MAHADEVAN_RESPONSE_TO_MP470_DN | 19 | 2.760 | 0 |
| WANG_TNF_TARGETS | 23 | 2.758 | 0 |
| BURTON_ADIPOGENESIS_1 | 33 | 2.742 | 0 |
| AMIT_EGF_RESPONSE_60_MCF10A | 38 | 2.735 | 0 |
| VOLTAGE_GATED_POTASSIUM_CHANNEL_COMPLEX | 29 | 2.689 | 0 |
| RORIE_TARGETS_OF_EWSR1_FLI1_FUSION_UP | 30 | 2.663 | 0 |
| (b) | |||
| REACTOME_G2_M_CHECKPOINTS | 41 | 1.865 | 0.00029 |
| REACTOME_MITOTIC_PROMETAPHASE | 85 | 1.822 | 0.00064 |
| REACTOME_MITOTIC_M_M_G1_PHASES | 167 | 1.783 | 0.00114 |
| REACTOME_G0_AND_EARLY_G1 | 23 | 1.732 | 0.00241 |
| REACTOME_CELL_CYCLE | 392 | 1.710 | 0.00314 |
| REACTOME_CELL_CYCLE_CHECKPOINTS | 111 | 1.690 | 0.00428 |
| REACTOME_S_PHASE | 106 | 1.660 | 0.00596 |
| REACTOME_M_G1_TRANSITION | 78 | 1.646 | 0.00706 |
| REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE | 77 | 1.621 | 0.00908 |
| (c) | |||
| GEORGES_CELL_CYCLE_MIR192_TARGETS | 62 | 1.726 | 0.00272 |
| TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C | 449 | 1.675 | 0.00501 |