Table 2.
Cox proportional hazards models showing mutually adjusted hazard ratios and their 95% confidence intervals for breast cancer mortality in women with diabetes.
| Variables | Interpretation | Mutually adjusted hazard ratio | 95% confidence interval | P value |
|---|---|---|---|---|
| Age | Every 1-year increase | 1.027 | (1.012, 1.042) | 0.0005 |
| Diabetes duration | Every 1-year increase | 1.017 | (0.995, 1.040) | 0.1298 |
| Diabetes type | Type 2 vs. Type 1 | 1.418 | (0.527, 3.814) | 0.4887 |
| Body mass index | Every 1-kg/m2 increase | 0.973 | (0.933, 1.015) | 0.2091 |
| Smoking | Yes vs. No | 1.000 | (0.442, 2.261) | 0.9995 |
| Insulin use | Yes vs. No | 1.339 | (0.782, 2.293) | 0.2878 |
| Area of residence | Urban vs. Rural | 1.294 | (0.955, 1.752) | 0.0958 |
|
| ||||
| Sensitivity analyses∗ | ||||
| Excluding patients who died of breast cancer within 3 years of diabetes onset | ||||
| Age | Every 1-year increase | 1.031 | (1.016, 1.047) | <0.0001 |
| Diabetes duration | Every 1-year increase | 1.020 | (0.998, 1.043) | 0.0719 |
| Diabetes type | Type 2 vs. Type 1 | 1.378 | (0.513, 3.706) | 0.5250 |
| Body mass index | Every 1-kg/m2 increase | 0.976 | (0.935, 1.020) | 0.2780 |
| Smoking | Yes vs. No | 1.047 | (0.462, 2.370) | 0.9126 |
| Insulin use | Yes vs. No | 1.384 | (0.806, 2.375) | 0.2387 |
| Area of residence | Urban vs. Rural | 1.333 | (0.976, 1.819) | 0.0705 |
∗Sensitivity analyses conducted after excluding patients who died of breast cancer within 5 years and 7 years of diabetes onset separately did not remarkably change the adjusted hazard ratios.