Table 1. Dysregulation of Foxp3-upregulated and Foxp3-downregulated genes by Foxp3 ProR subdomain mutations.

Condition	Number of dysregulated genes…		P value for comparison with all Foxp3- regulated genes
	…upregulated by Foxp3	…downregulated by Foxp3
TH::Foxp3∆ProR	1112	1031	0.82
TH::Foxp3∆FKH	311	202	1.2×10–4
TH::Foxp3∆FKHnls	265	129	1.5×10–9
TH::Foxp3∆E1	12	9	0.67
TH::Foxp3∆m4.2	95	127	5.7×10–3
TH::Foxp3∆m5	109	115	0.32

P values were calculated with binomial tests to compare the distribution of Foxp3-upregulated and—downregulated genes with the distribution within all 2,407 Foxp3-regulated, T_Reg-relevant genes.