Table 2. Analysis of immunology-related genes and enriched GO terms within gene lists.
| Gene list | Analysis of immune-related genes | Analysis of GO term enrichment | ||||
|---|---|---|---|---|---|---|
| Immunology-related genes | Non-immunology genes | Enrichment P value a | Immunology-related GO terms | Non-immunology GO-terms | P value for comparison with all Foxp3-related genes b | |
| All Foxp3-regulated, TReg relevant genes | 609 (25.3%) | 1798 (74.7%) | 2.1×10–69 | 34 (12.7%) | 234 (87.3%) | N/A |
| TH::Foxp3∆ProR | 556 (25.9%) | 1587 (74.06%) | 7.4×10–68 | 34 (13.2%) | 223 (86.8%) | 0.78 |
| TH::Foxp3∆FKH | 178 (34.7%) | 335 (65.3%) | 3.4×10–41 | 26 (26.3%) | 73 (73.7%) | 2.3×10–4 |
| TH::Foxp3∆FKHnls | 154 (39.1%) | 335 (65.3%) | 3.9×10–43 | 40 (32.3%) | 84 (67.7%) | 1.2×10–8 |
| TH::Foxp3∆E1 | 8 (38.1%) | 13 (61.9%) | 1.8×10–3 | 0 | 0 | N/A |
| TH::Foxp3∆m4.2 | 77 (34.7%) | 145 (65.3%) | 5.9×10–19 | 5 (7.6%) | 61 (92.4%) | 0.27 |
| TH::Foxp3∆m5 | 95 (42.41%) | 129 (57.6%) | 1.4×10–7 | 11 (19.0%) | 47 (81.0%) | 0.16 |
a P values calculated by Fisher’s exact test in comparison with all genes in mouse genome.
b P values calculated by Binomial test in comparison with distribution of immunology-related and non-immunology-related terms enriched in set of 2,407 Foxp3-regulated TReg-relevant genes.