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. Author manuscript; available in PMC: 2015 Jun 25.
Published in final edited form as: J Huntingtons Dis. 2014;3(3):311–316. doi: 10.3233/JHD-140110

Figure 2. Effects of GA treatment on in vitro (STHdh striatal cells) and in vivo (N171-82Q transgenic mice) HD phenotypes.

Figure 2

A). STHdh HD (Q111) and WT (Q7) striatal cells were treated with GA at the indicated concentrations and XTT assays performed after 24 hrs. Significant differences were determined by one-way ANOVA, followed by Dunnett’s post-test. **, P<0.001, ***, P<0.0001. B). Groups of mice were tested in an open field activity chamber over a 10 minute period and jumping activity and stereotypic behavior is shown. Two-way ANOVA revealed significant differences between WT-vehicle and N171-82Q-vehicle mice, as well as GA-treated vs. vehicle-treated N171-82Q transgenic mice in jumping counts (left) (**, P=0.001 and **P=0.001 for transgenic and drug effect, respectively) and stereotypic behavior (right) (**, p=0.0004 and **, P=0.009 for transgenic and drug effect, respectively).