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. Author manuscript; available in PMC: 2016 Mar 2.
Published in final edited form as: Angew Chem Int Ed Engl. 2015 Jan 22;54(10):3061–3064. doi: 10.1002/anie.201410043

Scheme 1.

Scheme 1

Interaction of an alkoxy group during hydrolysis: [a] formation of a new covalent bond in the transition state, and [b] electrostatic stabilization in the transition state.